Desperate times in the Reign of X! The mutants are dying. Krakoa is dying. Earth itself is dying. All hope for humanity as a species lies in S.W.O.R.D. and Protocol V. But Protocol V isn't going to work! Weeks ago, Synch, Darwin and X-23 stepped into the Vault. Now they are about to emerge - but inside the Vault, centuries have passed! What has become of them? The Marauders return to Madripoor to pay tribute to a fallen friend, but old enemies are being forged anew. And after a turbulent time with X-Force, death gives Quentin Quire a new lease on life. Long live Quentin Quire!